5-HYDROXYTRYPTAMINE UPTAKE INHIBITORS BLOCK para-METHOXYAMPHETAMINE-INDUCED 5-HT RELEASE
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منابع مشابه
Relationship between neonatal testosterone and 5-hydroxytryptamine (5 HT) in controlling the pattern of LH release in adult rats
Relationship between neonatal testosterone and 5-hydroxytryptamine (5-HT) in controlling the pattern of LH release in adult rats was investigated in this study. Hypothalamic 5-HT concentrations are transiently lower in male as compared to female Wistar rats in the second week post-partum (pp). It has also been shown that pharmacologically potentiating 5-HT activity during this period feminizes ...
متن کاملRelationship between neonatal testosterone and 5-hydroxytryptamine (5 HT) in controlling the pattern of LH release in adult rats
Relationship between neonatal testosterone and 5-hydroxytryptamine (5-HT) in controlling the pattern of LH release in adult rats was investigated in this study. Hypothalamic 5-HT concentrations are transiently lower in male as compared to female Wistar rats in the second week post-partum (pp). It has also been shown that pharmacologically potentiating 5-HT activity during this period feminizes ...
متن کاملEndogenous 5-HT outflow from chicken aorta by 5-HT uptake inhibitors and amphetamine derivatives.
Chemoreceptor cells aggregating in clusters in the chicken thoracic aorta contain 5-hydroxytryptamine (5-HT) and have voltage-dependent ion channels and nicotinic acetylcholine receptors, which are characteristics typically associated with neurons. The aim of the present study was to investigate the effects of 5-HT uptake inhibitors, fluvoxamine, fluoxetine and clomipramine (CLM), and amphetami...
متن کاملTemporal regulation of agonist efficacy at 5-hydroxytryptamine (5-HT)1A and 5-HT 1B receptors.
Coactivation of purinergic (P 2Y) receptors reduces agonist efficacy at serotonin 1B (5-HT 1B), but not 5-HT 1A receptors. Herein, we report that pretreatment for 5 min with the P 2Y receptor agonist ATP reduced agonist responsiveness at the 5-HT 1A, but not at the 5-HT 1B, receptor. The effect of ATP pretreatment on the 5-HT 1A receptor response rapidly reversed within a 10 min time frame betw...
متن کامل5-Hydroxytryptamine (5-HT) Cellular Sequestration during Chronic Exposure Delays 5-HT3 Receptor Resensitization due to Its Subsequent Release*
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors. We report that recombinantly expressed 5-HT3 receptor binding sites are reduced by chronic exposure to 5-HT (IC50 of 154.0 ± 45.7 μM, t½ = 28.6 mi...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1979
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1979.tb13663.x